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| | Methyl salvionolate A Basic information |
| Product Name: | Methyl salvionolate A | | Synonyms: | Methyl salvionolate A;(alphaR)-alpha-[[(2E)-3-[2-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid methyl ester;Benzenepropanoic acid, α-[[(2E)-3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, methyl ester, (αR)- | | CAS: | 1015171-69-3 | | MF: | C27H24O10 | | MW: | 508.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1015171-69-3.mol |  |
| | Methyl salvionolate A Chemical Properties |
| Boiling point | 824.5±65.0 °C(Predicted) | | density | 1.503±0.06 g/cm3(Predicted) | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 8.85±0.45(Predicted) |
| | Methyl salvionolate A Usage And Synthesis |
| Uses | Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC50 of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with
IC50s of 50.58, 10.73 and 7.58 μg/ml, respectively[1]. | | target | HIV | | References | [1] Wang Q, et al. Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis. J Nat Prod. 2018 Nov 26;81(11):2531-2538. DOI:10.1021/acs.jnatprod.8b00638
[2] Zhang ZF, et al. Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis. J Asian Nat Prod Res. 2008 May-Jun;10(5-6):391-6. DOI:10.1080/10286020801966591 |
| | Methyl salvionolate A Preparation Products And Raw materials |
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