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JP 1302 2HCl manufacturers
- JP 1302 2HCl
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2026-05-18
- CAS:1259314-65-2
- Min. Order: 1kg
- Purity: 98%
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| | JP 1302 2HCl Basic information |
| Product Name: | JP 1302 2HCl | | Synonyms: | JP 1302 2HCl;JP-1302 (hydrochloride);JP-1302 HCl;N-(4-(4-Methylpiperazin-1-yl)phenyl)acridin-9-amine dihydrochloride;Inhibitor,JP 1302,JP-1302,JP1302 dihydrochloride,inhibit,JP1302,Beta Receptor,Adrenergic Receptor,JP-1302 dihydrochloride;JP1302 dihydrochloride, alpha2C antagonist;JP1302 dihydrochloride, 10 mM in DMSO | | CAS: | 1259314-65-2 | | MF: | C24H25ClN4 | | MW: | 404.94 | | EINECS: | | | Product Categories: | | | Mol File: | 1259314-65-2.mol |  |
| | JP 1302 2HCl Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in water and to 5 mM in DMSO | | form | Powder | | color | Brown to reddish brown | | Water Solubility | Soluble to 100 mM in water |
| | JP 1302 2HCl Usage And Synthesis |
| Uses | JP 1302 Dihydrochloride is an α2-adrenoceptor blocker and can be used for the treatment or prevention of nephropathy. | | in vivo | JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine (HY-B1272A)[1].
JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats[1].
JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction[3]. | Animal Model: | Male Sprague Dawley rats (8 weeks old)[3] | | Dosage: | 3 mg/kg | | Administration: | IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion | | Result: | Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression. |
| | IC 50 | human α2C-adrenoceptor: 28±2 nM (Ki); human α2B-adrenoceptor: 1470±130 nM (Ki); human α2A-adrenoceptor: 3150±50 nM (Ki); rodent α2D-adrenoceptor: 1700±200 nM (Ki) | | storage | Store at -20°C |
| | JP 1302 2HCl Preparation Products And Raw materials |
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