| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:TAK-960 (hydrochloride)
CAS:1137868-96-2
Purity:>98% Package:866RMB/2mg
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Email: |
info@musechem.com |
| Products Intro: |
Product Name:TAK-960 hydrochloride
CAS:1137868-96-2
Purity:>98% HPLC Package:10mg;100mg;1g Remarks:Reagent Grade
|
| Company Name: |
Angel Pharmatech, Ltd.
|
| Tel: |
17317130613 |
| Email: |
3358272972@qq.com |
| Products Intro: |
Product Name:TAK-960 (hydrochloride)
CAS:1137868-96-2
Purity:98% HPLC Package:1G;5G
|
| Company Name: |
Absin Bioscience Inc.
|
| Tel: |
021-38015121 18438616290 |
| Email: |
lanwu@univ-bio.com |
| Products Intro: |
Product Name:TAK-960 hydrochloride
CAS:1137868-96-2
Package:5mg;2mg Remarks: 见爱必信官网
|
TAK-960 (hydrochloride) manufacturers
- TAK-960 hydrochloride
-
- $2500.00 / 100mg
-
2025-10-27
- CAS:1137868-96-2
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | TAK-960 (hydrochloride) Basic information |
| Product Name: | TAK-960 (hydrochloride) | | Synonyms: | TAK-960 (hydrochloride);TAK-960 HCl salt;TAK-960 HCl;4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hydrochloride | | CAS: | 1137868-96-2 | | MF: | C27H35ClF3N7O3 | | MW: | 598.07 | | EINECS: | | | Product Categories: | | | Mol File: | 1137868-96-2.mol |  |
| | TAK-960 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | TAK-960 (hydrochloride) Usage And Synthesis |
| Uses | TAK 960 Hydrochloride is a Polo-like kinase inhibitor. | | in vivo | TAK-960 hydrochloride exhibits (10 mg/kg; p.o.; once daily for 2 weeks) significant efficacy against multiple tumor xenografts[1].
In animal models, TAK-960 hydrochloride (p.o.) increases pHH3 in a dose-dependent manner and significantly inhibits the growth of HT-29 colorectal cancer xenografts[1]. | Animal Model: | nude mice or SCID mice (bearing HCT116, PC-3, BT474, A549, NCI-H1299, NCI-H1975, A2780, and MV4-11 cells)[1] | | Dosage: | 10 mg/kg | | Administration: | P.o.; once daily for 2 weeks | | Result: | Substantial antitumor activity and good tolerability.
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| | IC 50 | PLK1: 0.8 nM (IC50); PLK2: 16.9 nM (IC50); PLK3: 50.2 nM (IC50); FAK/PTK2: 19.6 nM (IC50); MLCK/MYLK: 25.6 nM (IC50); FES/FPS: 58.2 nM (IC50) |
| | TAK-960 (hydrochloride) Preparation Products And Raw materials |
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