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2-Morpholinoethanol

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CAS:622-40-2
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2-Morpholinoethanol manufacturers

  • 2-Morpholinoethanol
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  • CAS:622-40-2
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  • CAS:622-40-2
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  • CAS:622-40-2
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2-Morpholinoethanol Basic information
Product Name:2-Morpholinoethanol
Synonyms:2-(morpholinyl)-ethano;2-morpholino-ethano;beta-Morpholinoethanol;beta-Oxyaethyl-morpholin;Ethanol, 2-(morpholinyl)-;Ethanol, 2-morpholino-;hydroxyethylmorpholine;Morpholine-4-ethanol
CAS:622-40-2
MF:C6H13NO2
MW:131.17
EINECS:210-734-5
Product Categories:Building Blocks;C4 to C10;Chemical Synthesis;Heterocyclic Building Blocks;Morpholines/Thiomorpholines
Mol File:622-40-2.mol
2-Morpholinoethanol Structure
2-Morpholinoethanol Chemical Properties
Melting point -1 °C
Boiling point 227 °C757 mm Hg(lit.)
density 1.083 g/mL at 25 °C(lit.)
vapor pressure 2.44-7Pa at 20-25℃
refractive index n20/D 1.476(lit.)
Fp 211 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka14.88±0.10(Predicted)
form Liquid
color Clear colorless to yellow
PH10.7 (100g/l, H2O, 20℃)
explosive limit1.5-9.8%(V)
Water Solubility miscible
BRN 104375
InChI1S/C6H13NO2/c8-4-1-7-2-5-9-6-3-7/h8H,1-6H2
InChIKeyKKFDCBRMNNSAAW-UHFFFAOYSA-N
SMILESOCCN1CCOCC1
LogP-1.32 at 25℃
CAS DataBase Reference622-40-2(CAS DataBase Reference)
NIST Chemistry Reference4-Morpholineethanol(622-40-2)
EPA Substance Registry System4-Morpholineethanol (622-40-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 1
RTECS QE3510000
10-23
TSCA TSCA listed
HS Code 29349990
Storage Class10 - Combustible liquids
Hazard ClassificationsEye Irrit. 2
MSDS Information
ProviderLanguage
2-Morpholinoethanol English
SigmaAldrich English
ACROS English
ALFA English
2-Morpholinoethanol Usage And Synthesis
Chemical Properties2-Morpholinoethanol is a transparent colorless to yellow liquid. It is used as an organic chemical synthesis intermediate.
Uses4-(2-Hydroxyethyl)morpholine is a morphiline derivative used in the preparation of ester prodrugs of naproxen. 4-(2-Hydroxyethyl)morpholine was also shown to induce repair in rat hepatocyte primary cu lture/DNA.
DefinitionChEBI: 2-Morpholinoethanol is a primary alcohol that is ethanol in which one of the methyl hydrogens is replaced by a morpholin-4-yl group. It is a primary alcohol, a tertiary amino compound and a member of morpholines.
Synthesis Reference(s)The Journal of Organic Chemistry, 52, p. 467, 1987 DOI: 10.1021/jo00379a035
Flammability and ExplosibilityNon flammable
References[1] Journal of the Indian Chemical Society, 1989, vol. 66, # 5, p. 316 - 318
[2] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00498
[3] Patent: US2015/87639, 2015, A1. Location in patent: Paragraph 0849; 0850
[4] Patent: TWI607995, 2017, B. Location in patent: Page/Page column 180
[5] Journal of Organic Chemistry, 2018, vol. 83, # 24, p. 15333 - 15346
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