H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
| 中文名称 | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH |
|---|---|
| 中文同义词 | LARAZOTIDE ACETATE (> 90%);2-((S)-1-((2S,5S,8S,11S)-17-氨基-2-(3-氨基-3-氧代丙基)-8-异丁基-5,11-二异丙基-4,7,10,13,16-五氧代-3,6,9,12,15-五氮杂十七烷-1-酰基)吡咯烷-2-羧酰胺基)乙酸 乙酸盐;化合物LARAZOTIDE ACETATE;拉瑞唑来乙酸盐;2-((S)-1-((2S,5S,8S,11S)-17-氨基-2-(3-氨基-3-氧代丙基)-8-异丁基-5,11-二异丙基-4,7,10,13,16-五氧代-3,6,9,12,15-五氮杂十七烷-1-酰基)吡咯烷-2-羧酰胺基)乙酸 乙酸;拉雷佐肽;Larazotide acetate试剂;Larazotide acetate试剂 |
| 英文名称 | Larazotide |
| 英文同义词 | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH;Larazotide acetate;LARAZOTIDE ACETATE (> 90%);inhibit,Larazotide acetate,Larazotide,Inhibitor,Gap Junction Protein;Larazotide acetate salt;AT-1001 (Larazotide acetate) |
| CAS号 | 881851-50-9 |
| 分子式 | C34H59N9O12 |
| 分子量 | 785.88536 |
| EINECS号 | |
| 相关类别 | 定制肽;多肽中间体 |
| Mol文件 | 881851-50-9.mol |
| 结构式 |  |
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 性质
| 熔点 | >231°C (dec.) |
|---|---|
| 储存条件 | Refrigerator |
| 溶解度 | 可微溶于水 |
| 形态 | 固体 |
| 颜色 | 白色 |
| InChIKey | NYGCNONRVCGHAT-FTIBEKKFNA-N |
| SMILES | C(O)(=O)C.C(O)(=O)CNC([C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(CNC(CN)=O)=O)C(C)C)CC(C)C)C(C)C)CCC(N)=O)=O |&1:10,17,21,25,29,r| |
Paracellular permeability
Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate | 881851-50-9 | 1mg | 586元 |
| 2025/12/22 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate | 881851-50-9 | 5mg | 997元 |