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| | 7-bromoimidazo[1,5-a]pyridine Basic information |
| | 7-bromoimidazo[1,5-a]pyridine Chemical Properties |
| density | 1.69±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 6.02±0.30(Predicted) | | Appearance | Yellow to brown Solid | | CAS DataBase Reference | 865156-48-5 |
| | 7-bromoimidazo[1,5-a]pyridine Usage And Synthesis |
| Uses | 7-Bromoimidazo[1,5-a]pyridine is used in the discovery of novel imidazopyridine GSK-3β inhibitors supported by computational approaches. | | Synthesis | General procedure for the synthesis of 7-bromoimidazo[1,5-a]pyridine from N-((4-bromopyridin-2-yl)methyl)formamide: To a 100 mL round bottom flask was added a solution of N-((4-bromopyridin-2-yl)methyl)formamide (Compound 39.2, 3.0 g, 90%, 12.6 mmol) in dichloromethane (20 mL). The solution was cooled to 0-5 °C and then trifluoroacetic anhydride (1.93 mL, 13.9 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 1 h. Subsequently, the pH was adjusted to 7 by slow addition of saturated aqueous sodium carbonate solution. The aqueous phase was extracted with dichloromethane (3 x 20 mL), the organic layers were combined and washed with brine (3 x 20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1/1) as eluent to afford 7-bromoimidazo[1,5-a]pyridine as a brown solid. | | References | [1] Patent: WO2014/8197, 2014, A1. Location in patent: Page/Page column 106; 107
[2] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 121; 122
[3] Patent: WO2005/90305, 2005, A1. Location in patent: Page/Page column 29-30
[4] Patent: WO2005/90304, 2005, A1. Location in patent: Page/Page column 38 |
| | 7-bromoimidazo[1,5-a]pyridine Preparation Products And Raw materials |
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