| Company Name: |
Musechem |
| Tel: |
+1-800-259-7612 |
| Email: |
info@musechem.com |
DPC-681 manufacturers
- DPC-681
-
- $571.00
-
2026-07-27
- CAS:284661-68-3
- Purity:
- Supply Ability: 10g
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| | DPC-681 Basic information |
| Product Name: | DPC-681 | | Synonyms: | DPC-681;DPH-153893;L-Valinamide, N-[(3-fluorophenyl)methyl]glycyl-N-[(1S,2R)-3-[[(3-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-;DPC-681 (DPH-153893);DPC 681,DPC681;(S)-N-((2S,3R)-4-((3-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-2-(2-((3-fluorobenzyl)amino)acetamido)-3,3-dimethylbutanamide | | CAS: | 284661-68-3 | | MF: | C35H48FN5O5S | | MW: | 669.85 | | EINECS: | | | Product Categories: | | | Mol File: | 284661-68-3.mol |  |
| | DPC-681 Chemical Properties |
| density | 1.217±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 13.52±0.20(Predicted) | | color | White to off-white |
| | DPC-681 Usage And Synthesis |
| Uses | DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.
IC50 value: 4 - 40 nM [1]
Target: HIV protease
in vitro: DPC 681 is extremely potent inhibitor of wild-type HIV-1. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681. DPC 681 shows no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. [1]
in vivo: The total body clearance (CL) of DPC 681 in dogs was high (1.8 liter/h/kg) equaling hepatic blood flow for this species (1.8 liter/h/kg). After an oral dosing, the Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively). These data suggest that hepatic extraction (first-pass effect) can be saturated in the dog. [1] | | IC 50 | HIV-1 | | References | [1] Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8. DOI:10.1128/AAC.45.11.3021-3028.2001 |
| | DPC-681 Preparation Products And Raw materials |
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