FITM manufacturers
- FITM
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- $30.00 / 1mg
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2026-04-22
- CAS:932737-65-0
- Min. Order:
- Purity: 99.23%
- Supply Ability: 10g
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| Product Name: | FITM | | Synonyms: | FITM;4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide;Benzamide, 4-fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]-;4-fluoro-N-methyl-N-[4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]benzamide;FITM,mGluR,Metabotropic glutamate receptors,inhibit,Inhibitor;4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide;FITM, 10 mM in DMSO | | CAS: | 932737-65-0 | | MF: | C18H18FN5OS | | MW: | 371.43 | | EINECS: | | | Product Categories: | | | Mol File: | 932737-65-0.mol |  |
| Boiling point | 573.9±60.0 °C(Predicted) | | density | 1.334±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100mM; Ethanol: 20mM | | form | A crystalline solid | | pka | 3.03±0.10(Predicted) | | color | White to off-white |
| Uses | 4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide is a potent mGluR1 antagonist. It also demonstrats a relatively potent antipyschotic-like effect in several animal models, suitable for the development of a PET tracer. | | in vivo | The pretreatment of rats with unlabeled FITM (1 mg/kg) occupies an mGluR1 binding site of 18F-FITM by more than 99% and does not affect the input function. The Kd (nM) and Bmax (pmol/mL) obtained by the Scatchard analyses with the multidose ligand assays are 2.1 and 36.3, respectively, for the thalamus; 2.1 and 27.5, respectively, for the hippocampus; 1.5 and 22.2, respectively, for the striatum; and 1.5 and 20.5, respectively, for the cingulate cortex with a high confidence[3]. 18F-FITM shows excellent pharmacokinetics, namely the dense and specific accumulation in mGlu1-positive melanomas versus mGlu1-negative hepatoma and normal tissues. Furthermore, the accumulation levels of radioactivity corresponded to the extent of tumor and to levels of mGlu1 protein expression in melanomas and melanoma metastasis[4]. | | IC 50 | mGlu1: 2.5 nM (Ki) | | storage | Store at -20°C |
| | FITM Preparation Products And Raw materials |
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