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| | GLP-1 (28-36)amide Basic information |
| Product Name: | GLP-1 (28-36)amide | | Synonyms: | GLP-1 (28-36)amide;L-Argininamide, L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-;(S)-2-((2S,5S,8S,11S,14S,17S)-8-((1H-Indol-3-yl)methyl)-17-amino-14-((S)-sec-butyl)-5-isobutyl-2-isopropyl-11-methyl-4,7,10,13,16-pentaoxo-18-phenyl-3,6,9,12,15-pentaazaoctadecanamido)-6-amino-N-(2-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-2-oxoethyl)hexanamide | | CAS: | 1225021-13-5 | | MF: | C54H85N15O9 | | MW: | 1088.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1225021-13-5.mol |  |
| | GLP-1 (28-36)amide Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | form | Solid | | pka | 13.30±0.46(Predicted) | | color | White to off-white | | Sequence | Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 |
| | GLP-1 (28-36)amide Usage And Synthesis |
| Uses | GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide has anti-diabetic and cardioprotection effects[1]. | | in vivo | The administration of GLP-1(28-36)amide at a rate of 18.5 nmol/kg BW/day for 9 weeks to diet-induced obese mice diminishes the development of hepatic steatosis[1].
The intraperitoneal injection of 18 nmol/kg GLP-1(28-36)amide once daily for 9 weeks show cytoprotective effect on pancreatic β cells by increasing mass and promoting proliferation in a β-cell injury diabetic mouse model[1].
An in vivo study in high-fat diet-fed mice indicates that a six-week administration of 18.5 nmol/kg GLP-1(28-36)amide improved hepatic glucose disposal, which is associated with increased cAMP levels and phosphorylation of PKA target[1].
Administered GLP-1(28-36)amide for 20 min to male C57BL6/J mice (10-12 week old), then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure (LVDP) is significantly greater in GLP-1(28-36)amide group compared to vehicle-treated hearts[1]. | | References | [1] Bilan Zhou, et al. GLP-1(28-36)amide, a Long Ignored Peptide Revisited. Open Biochem J. 2014 Dec 31;8:107-11. DOI:10.2174/1874091X01408010107 |
| | GLP-1 (28-36)amide Preparation Products And Raw materials |
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