Rp-8-CPT-Cyclic AMP (sodium salt) manufacturers
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| | Rp-8-CPT-Cyclic AMP (sodium salt) Basic information |
| Product Name: | Rp-8-CPT-Cyclic AMP (sodium salt) | | Synonyms: | Rp-8-CPT-Cyclic AMP (sodium salt);VXMLCXRTUQHZAI-ALHPSJIMSA-N;Rp-8-CPT-cAMPS sodium;Rp-8-CPT-Cyclic AMP sodium salt (Rp-8-CPT-cAMP);Reaxys ID: 27584458 | | CAS: | 221905-35-7 | | MF: | C16H16ClN5NaO5PS2 | | MW: | 511.87 | | EINECS: | | | Product Categories: | | | Mol File: | 221905-35-7.mol |  |
| | Rp-8-CPT-Cyclic AMP (sodium salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.5 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | Rp-8-CPT-Cyclic AMP (sodium salt) Usage And Synthesis |
| Description | Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS . It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II. By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation. | | Uses | Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS . It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II. By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[Cayman Chemical] | | Uses | Rp-8-CPT-Cyclic AMP (Sodium Salt) is a combination of lipophilic and hydrolizable cAMP analogs. Functions thus as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference for site a type I and site B type II. | | References | [1] FRANK SCHWEDE . Cyclic nucleotide analogs as biochemical tools and prospective drugs[J]. Pharmacology & Therapeutics, 2000, 87 2: Pages 199-226. DOI: 10.1016/s0163-7258(00)00051-6
[2] W R DOSTMANN. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3’,5’-cyclic phosphorothioates.[J]. The Journal of Biological Chemistry, 1990, 265 18: 10484-10491.
[3] B T GJERTSEN. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action.[J]. The Journal of Biological Chemistry, 1995, 270 35: 20599-20607. DOI: 10.1074/jbc.270.35.20599 |
| | Rp-8-CPT-Cyclic AMP (sodium salt) Preparation Products And Raw materials |
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