4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)

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4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid) Basic information
Product Name:4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)
Synonyms:4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid);4,4-(4,4-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)(WX610172);2-Butenoic acid, 4,4'-([1,1'-biphenyl]-4,4'-diyldiimino)bis[4-oxo-;(E)-4-[4-[4-[[(E)-3-carboxyprop-2-enoyl]amino]phenyl]anilino]-4-oxobut-2-enoic acid;LPA2 antagonist 2,LPA-2 antagonist 2;4,4'-([1,1'-Biphenyl]-4,4'-diylbis(azanediyl))bis(4-oxobut-2-enoic acid)
CAS:36840-10-5
MF:C20H16N2O6
MW:380.35
EINECS:
Product Categories:
Mol File:36840-10-5.mol
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid) Structure
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid) Chemical Properties
Boiling point 758.0±60.0 °C(Predicted)
density 1.444±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 83.33 mg/mL (219.09 mM)
pka3.16±0.10(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid) Usage And Synthesis
UsesLPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM)[1].
Biological ActivityLPA2 antagonist 2 is a selective LPA2 antagonist with IC50 of 28.3 nM and Ki of 21.1 nM, >480-fold selectivity over LPA3 (IC50 of 13.85 μM).
in vitroLysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation.
target

IC50: 28.3 nM (LPA 2 ); 13.85 μM (LPA 3 )

References[1] Fells JI, et al. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17. DOI:10.1016/j.bmc.2008.04.035
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid) Preparation Products And Raw materials
Tag:4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)(36840-10-5) Related Product Information
N-(3-BroMophenyl)MaleaMic acid, 97% 2-Butenoic acid, 4-[(3-ethynylphenyl)amino]-4-oxo-, (2Z)- NSC112781 (Z)-4-(2,4-dimethylanilino)-4-oxo-2-butenoic acid 4-{3-[(aminocarbonyl)amino]anilino}-4-oxo-2-butenoicacid (E)-4-(4-anilinoanilino)-4-oxo-2-butenoic acid