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| | Crotonyloxymethyl-4,5,6-trihydro-oxycyclohex-2-enone Basic information |
| | Crotonyloxymethyl-4,5,6-trihydro-oxycyclohex-2-enone Chemical Properties |
| Melting point | 181°C | | Boiling point | 345.05°C (rough estimate) | | density | 1.3367 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | -20°C | | solubility | DMSO: soluble,Methanol: soluble, | | pka | 11.668±0.70(predicted) | | form | A solid | | Water Solubility | Water: soluble |
| | Crotonyloxymethyl-4,5,6-trihydro-oxycyclohex-2-enone Usage And Synthesis |
| Uses | COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC50 = 18 μg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model[1]. | | References | [1] Takeuchi T, et al. A glyoxalase I inhibitor of a new structural type produced by Streptomyces. J Antibiot (Tokyo). 1975 Oct;28(10):737-42. DOI:10.7164/antibiotics.28.737 |
| | Crotonyloxymethyl-4,5,6-trihydro-oxycyclohex-2-enone Preparation Products And Raw materials |
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