- H-L-Phe-OBzl.HCl
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- $0.00 / 1kg
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2026-03-20
- CAS:2462-32-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | L-Phenylalanine benzyl ester hydrochloride Basic information |
| | L-Phenylalanine benzyl ester hydrochloride Chemical Properties |
| Melting point | 197-200 °C | | alpha | -13 º (c=1% in 80% acetic acid) | | refractive index | -12 ° (C=1, 80% acetic acid) | | storage temp. | Inert atmosphere,Room Temperature | | Water Solubility | Soluble in water | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Crystalline Powder | | color | White to off-white | | Optical Rotation | [α]20/D 13±1°, c = 1% in acetic acid: water (4:1) | | BRN | 3919200 | | Major Application | peptide synthesis | | InChI | InChI=1/C16H17NO2.ClH/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H/t15-;/s3 | | InChIKey | CEXFHIYDTRNBJD-AVAJOTNLNA-N | | SMILES | C1(=CC=CC=C1)C[C@H](N)C(=O)OCC1C=CC=CC=1.Cl |&1:7,r| | | CAS DataBase Reference | 2462-32-0(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29224999 | | Storage Class | 11 - Combustible Solids |
| | L-Phenylalanine benzyl ester hydrochloride Usage And Synthesis |
| Chemical Properties | White crystal | | Uses | L-Phenylalanine Benzyl Ester Hydrochloride is a commonly used reactant for the synthesis of L-isoserine derivatives as aminopeptidase N inhibitors and PF-04449913 as a potent and orally bioavailable inhibitor of smoothened. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | The general procedure for the synthesis of L-phenylalanine benzyl ester hydrochloride from (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropionate was as follows: benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenylpropionate (12.8 g, 36 mmol) was dissolved in an ether solution of 2 M HCl (90 mL) and a dioxane solution of 4 M HCl (18 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was diluted with hexane (100 mL) and subsequently filtered to afford L-phenylalanine benzyl ester hydrochloride (7.98 g, 76% yield) as a white fine powder. The product was characterized by 1H NMR (CD3OD, 400 MHz): δ (ppm) 7.40-7.15 (m, 10H), 5.23 (s, 2H), 4.36-4.31 (m, 1H), 3.26-3.12 (m, 2H). | | References | [1] Journal of Organic Chemistry, 2015, vol. 80, # 9, p. 4235 - 4243
[2] Patent: US9441012, 2016, B2. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 14, p. 1497 - 1499
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 2, p. 302 - 310
[5] Chemistry - A European Journal, 2012, vol. 18, # 21, p. 6528 - 6541 |
| | L-Phenylalanine benzyl ester hydrochloride Preparation Products And Raw materials |
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