N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine

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Company Name: Block Chemical Technology (Shanghai) Co., Ltd.  
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Company Name: Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine Basic information
Product Name:N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine
Synonyms:N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine;9H-Purin-2-amine, N-(4-fluorophenyl)-6-(4-morpholinyl)-;Topoisomerase IIα-IN-8;N-(4-Fluorophenyl)-6-(morpholin-4-yl)-9H-purin-2-amine;Topoisomerase
CAS:1251578-67-2
MF:C15H15FN6O
MW:314.32
EINECS:
Product Categories:
Mol File:1251578-67-2.mol
N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine Structure
N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine Chemical Properties
Boiling point 637.4±65.0 °C(Predicted)
density 1.461±0.06 g/cm3(Predicted)
storage temp. Store at 0-8 °C
form Powder
pka10.96±0.10(Predicted)
Safety Information
MSDS Information
N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine Usage And Synthesis
UsesTopoisomerase IIα-IN-8 (compound 15) is a weak human DNA topoisomerase IIa (htIIa) inhibitor, with an IC50 of 462 ± 38.0 μM[1].
IC 50topoisomerase II alpha
References[1] Barbara Pogorelnik, et al. Discovery of Mono- and Disubstituted 1H-Pyrazolo[3,4]pyrimidines and 9H-Purines as Catalytic Inhibitors of Human DNA TopoisomeraseII. ChemMedChem, 2015.
N-(4-Fluorophenyl)-6-morpholino-9H-purin-2-amine Preparation Products And Raw materials
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