(S)-Tetrahydro-2H-pyran-3-amine hydrochloride

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(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Basic information
Product Name:(S)-Tetrahydro-2H-pyran-3-amine hydrochloride
Synonyms:(S)-Tetrahydro-2H-pyran-3-amine hydrochloride;(S)-TETRAHYDRO-2H-PYRAN-3-AMINE HCL;(S)-tetrahydro-2H-pyran-3-amine hydrochloride(WXC09058S1);(S)-Tetrahydro-2H-pyran-3-amine 2hydrochloride;2H-Pyran-3-amine, tetrahydro-, hydrochloride (1:1), (3S)-
CAS:1245724-46-2
MF:C5H12ClNO
MW:137.61
EINECS:
Product Categories:
Mol File:1245724-46-2.mol
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Structure
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Chemical Properties
storage temp. Store at room temperature, keep dry and cool
AppearanceOff-white to light brown Solid
Safety Information
MSDS Information
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Usage And Synthesis
Synthesis
Carbamic acid, N-[(3S)-tetrahydro-2H-pyran-3-yl]-, 1,1-dimethylethyl ester

1295722-66-5

(S)-Tetrahydro-2H-pyran-3-amine hydrochloride

1245724-46-2

General procedure for the synthesis of (S)-3-aminotetrahydropyran hydrochloride from the compound (CAS: 1295722-66-5): the intermediate (S)-tert-butyltetrahydro-2H-pyran-3-ylcarbamate (414 g, 2.06 mol) was added to a methanolic solution (4 L) of 6 N HCl, and the reaction mixture was stirred at room temperature until the reaction was complete (monitored by TLC monitoring). Upon completion of the reaction, the mixture was concentrated under vacuum to afford 283 g of (S)-(tetrahydropyran-3-yl)amine hydrochloride as a white solid (99.8% yield, enantiomeric excess >99%). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.37 (s, 3H), 3.87-3.72 (m, 1H), 3.70-3.57 (m, 1H), 3.54-3.38 (m, 2H), 3.12 (d, J = 2.1 Hz, 1H), 2.05-1.89 (m, 1H), 1.81 -1.60 (m, 2H), 1.49 (dtd, J = 12.5, 8.3, 4.3 Hz, 1H).

References[1] Patent: WO2013/7768, 2013, A1. Location in patent: Page/Page column 110; 111
[2] Synlett, 2013, vol. 24, # 8, p. 987 - 990
(S)-Tetrahydro-2H-pyran-3-amine hydrochloride Preparation Products And Raw materials
Raw materialsCarbamic acid, N-[(3S)-tetrahydro-2H-pyran-3-yl]-, 1,1-dimethylethyl ester-->Hydrochloric acid-->Methanol
Tag:(S)-Tetrahydro-2H-pyran-3-amine hydrochloride(1245724-46-2) Related Product Information
Tetrahydro-pyran-3-ylamine hydrochloride (R)-Tetrahydro-2H-pyran-3-amine hydrochloride 2H-Pyran-3-amine, tetrahydro- (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate (S)-Tetrahydro-2H-pyran-3-amine hydrochloride (R)-tetrahydro-2H-pyran-3-amine hydrochloride