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| | 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Basic information |
| | 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Chemical Properties |
| Boiling point | 117-120 °C5 mm Hg(lit.) | | density | 1.16 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.458(lit.) | | Fp | 225 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly) | | pka | 14.36±0.10(Predicted) | | form | Liquid | | color | Clear slightly yellow | | BRN | 1739194 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | InChI | InChI=1S/C6H13ClO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-6H2 | | InChIKey | KECMLGZOQMJIBM-UHFFFAOYSA-N | | SMILES | C(O)COCCOCCCl | | CAS DataBase Reference | 5197-62-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | HS Code | 29094990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Usage And Synthesis |
| Chemical Properties | colourless liquid | | Uses | 2-[2-(2-Chloroethoxy)ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2-(2-Chloroethoxy)ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection. | | Uses | 2-[2-(2-Chloroethoxy)ethoxy]ethanol was used in the synthesis of 1-[3-(2-aminoethyl)-1H-indol-5-yloxy]-3,6-dioxa-8-mercaptooctane. It was also used in the synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3′-end and other modifications at the 5′-end. | | Synthesis | The reaction material in the three-necked flask was cooled to 45-50°C and 0.7 g of boron trifluoride diethyl ether compound was added as catalyst. Subsequently, 46.2 g (1.05 mol) of ethylene oxide was slowly added under stirring conditions, and the addition rate was controlled to maintain the reaction temperature at 45-55°C, using a temperature-controlled water bath for temperature adjustment if necessary. After the addition, the reaction was continued with stirring for 0.5 h to ensure complete reaction. Upon completion of the reaction, the reaction was heated and distilled under reduced pressure to collect the middle fraction at 115-123°C (vacuum 10 mmHg) to obtain a colorless transparent liquid. Further vacuum distillation was carried out under reduced pressure to collect the middle fraction at 118-121 °C (vacuum 10 mmHg) to give 123.6 g of colorless transparent liquid with 97.7% purity in the gas phase and 73.3% overall yield. | | References | [1] Patent: CN104003850, 2016, B. Location in patent: Paragraph 0039; 0040 |
| | 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL Preparation Products And Raw materials |
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