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3'-Azido-3'-deoxy-N6,N6-dimethyladenosine manufacturers
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| | 3'-Azido-3'-deoxy-N6,N6-dimethyladenosine Basic information |
| Product Name: | 3'-Azido-3'-deoxy-N6,N6-dimethyladenosine | | Synonyms: | 3'-Azido-3'-deoxy-N6,N6-dimethyladenosine;3'-Azido-3'-deoxy-N6-dimethyladenosine;3’-Azido-3’-deoxy-N6,N6-dimethyladenosine;4-azido-2-(6-(dimethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol | | CAS: | 384334-64-9 | | MF: | C12H16N8O3 | | MW: | 320.31 | | EINECS: | | | Product Categories: | | | Mol File: | 384334-64-9.mol |  |
| | 3'-Azido-3'-deoxy-N6,N6-dimethyladenosine Chemical Properties |
| pka | 12.688±0.70(predicted) |
| | 3'-Azido-3'-deoxy-N6,N6-dimethyladenosine Usage And Synthesis |
| Uses | 3’-Azido-3’-deoxy-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-N6,N6-dimethyladenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
| | 3'-Azido-3'-deoxy-N6,N6-dimethyladenosine Preparation Products And Raw materials |
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