251994-14-6
| 中文名称 | 251994-14-6 |
|---|---|
| 中文同义词 | 化合物 T13147;化合物ICAM-1-IN-1;4-(4-溴苯氧基)-N-甲基噻吩并[2,3-C]吡啶-2-甲酰胺;化合物ICAM-1-IN-1,10 MM DMSO 溶液 |
| 英文名称 | Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl- |
| 英文同义词 | ICAM-1 inhibitor 1;Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-;CAM-IN-1;ICAM 1 IN 1,inhibit,ICAM1IN1,Inhibitor,Integrin;4-(4-Bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide;ICAM-1-IN-1, 10 mM in DMSO |
| CAS号 | 251994-14-6 |
| 分子式 | C15H11BrN2O2S |
| 分子量 | 363.23 |
| EINECS号 | |
| 相关类别 | 对照品 |
| Mol文件 | 251994-14-6.mol |
| 结构式 |  |
251994-14-6 性质
| 熔点 | 78-80 °C |
|---|---|
| 沸点 | 579.6±45.0 °C(Predicted) |
| 密度 | 1.556±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥ 135 mg/mL（371.67 mM） |
| 酸度系数(pKa) | 13.70±0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
ICAM-1-IN-1 是有效，选择性的 E-selectin 和 ICAM-1 抑制剂，IC50值分别为7和5 nM。
IC50: 7 nM (E-selectin), 5 nM (ICAM-1)
ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.