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Product Name:CMP5
CAS:1030021-40-9
Purity:99% Remarks:Reach out to us for more information about custom solutions.
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CMP5 manufacturers
- CMP-5 hydrochloride
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- $2500.00 / 100mg
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2025-07-18
- CAS:1030021-40-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | CMP5 | | Synonyms: | CMP-5 hydrochloride
(PRMT5-IN-5);CMP5;CMP-5 hydrochloride;CMP 5 hydrochloride,CMP5 hydrochloride | | CAS: | 1030021-40-9 | | MF: | C21H22ClN3 | | MW: | 351.88 | | EINECS: | | | Product Categories: | | | Mol File: | 1030021-40-9.mol |  |
| Description | CMP5 is a potent and selective PRMT5 Inhibitor. CMP5 showed to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 μM. CMP-5 shows promise as a novel therapeutic_x000D_
approach for B-cell lymphomas. | | Uses | CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2]. | | References | [1] Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. DOI:10.1182/blood-2014-12-619783
[2] Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol.?2017?Feb 15;198(4):1439-1451. DOI:10.4049/jimmunol.1601702 |
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