tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate manufacturers
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| | tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Basic information |
| Product Name: | tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate | | Synonyms: | tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-2-fluorophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid,4-[[[4-(4-amino-2-fluorophenoxy)...;6-Methoxy-7-(N-BOC-4-piperidinemethoxy)-4-(2-fluoro-4-amino-phenoxy)-quinoline;6-Methoxy-7- (N-BOC-4 piperidimethoxy) -4- (2-fluoro-4-amino phenoxy) - quinoline | | CAS: | 929252-65-3 | | MF: | C27H32FN3O5 | | MW: | 497.56 | | EINECS: | | | Product Categories: | | | Mol File: | 929252-65-3.mol |  |
| | tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Chemical Properties |
| Boiling point | 619.7±55.0 °C(Predicted) | | density | 1.235±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 5.42±0.30(Predicted) |
| | tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Usage And Synthesis |
| Synthesis | Step 4. Synthesis of tert-butyl 4-(((4-(4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate (81): to a mixture of ethanol (8 mL) and water (4 mL) of Compound 80 (0.50 g, 0.95 mmol) was added iron powder (0.254 g, 4.55 mmol) and ammonium chloride ( 0.123 g, 2.26 mmol). The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the reaction mixture was diluted with methanol and filtered to remove the solid suspension. The filtrate was concentrated and the resulting residue was purified by a Gilson automated purification system (eluent gradient: 35% to 57% methanol/dichloromethane) to afford the target product 4-(((4-(4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester 81 (0.25 g, 52% yield). | | References | [1] Patent: US2008/4273, 2008, A1. Location in patent: Page/Page column 79; 80
[2] Patent: US2007/60613, 2007, A1. Location in patent: Page/Page column 17-18 |
| | tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Preparation Products And Raw materials |
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