| Company Name: |
BioBioPha Co., Ltd.
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| Tel: |
0871-65217109 13211707573; |
| Email: |
y.liu@mail.biobiopha.com |
| Products Intro: |
Product Name:Secoisolariciresinol diglucoside
CAS:257930-74-8
Purity:99.0% Package:5mg Remarks:BBP04029
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| Company Name: |
ShangHai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847 13636370518 |
| Email: |
shyysw007@163.com |
| Products Intro: |
Product Name:Secoisolariciresinol diglucoside
CAS:257930-74-8
Purity:HPLC>=96.5% Package:5mg Remarks:B36167
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| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:Secoisolariciresinoldiglucoside/(SS)-Secoisolariciresinoldiglucoside
CAS:257930-74-8
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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| | Secoisolariciresinol diglucoside Basic information |
| Product Name: | Secoisolariciresinol diglucoside | | Synonyms: | β-D-Glucopyranoside, (2S,3S)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediyl bis-;Secoisolariciresinoldiglucoside/(SS)-Secoisolariciresinoldiglucoside;(S,S)-SDG;(S,S)-Secoisolariciresinol diglucoside | | CAS: | 257930-74-8 | | MF: | C32H46O16 | | MW: | 686.7 | | EINECS: | | | Product Categories: | | | Mol File: | 257930-74-8.mol |  |
| | Secoisolariciresinol diglucoside Chemical Properties |
| Boiling point | 989.2±65.0 °C(Predicted) | | density | 1.52±0.1 g/cm3(Predicted) | | form | Solid | | pka | 9.80±0.20(Predicted) | | color | White to off-white |
| | Secoisolariciresinol diglucoside Usage And Synthesis |
| Uses | Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects[1][2]. | | Biological Activity | Secoisolariciresinol diglucoside ((S,S)-SDG), the major lignan in whole wheat flaxseed, has anti-inflammatory, antioxidant, anti-mutagenic, antimicrobial, anti-obesity, hypolipidemic and neuroprotective effects. | | in vitro | Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals. | | in vivo | Secoisolariciresinol diglucoside (4 mg/mouse; a single po) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation. | Animal Model: < /td> | Hand feeding mice (10 weeks old, male) are injected with TNFα | | Dosage: | 4 mg/mouse | | Administration: | Po 2 h before ic administration of TNFα | | Result: | Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%. | | | References | [1] Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8. DOI:10.1016/j.bmcl.2013.07.062
[2] Rom S, et, al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018 Jan 27;15(1):25. DOI:10.1186/s12974-018-1065-0 |
| | Secoisolariciresinol diglucoside Preparation Products And Raw materials |
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