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| | OBDXBUWPBDVKEB-KSSFIOAISA-N Basic information |
| Product Name: | OBDXBUWPBDVKEB-KSSFIOAISA-N | | Synonyms: | OBDXBUWPBDVKEB-KSSFIOAISA-N;(4S,5S)-tert-butyl 4-(((benzyloxy)carbonyl)amino)-5-methyl-3-oxoheptanoate;Heptanoic acid, 5-methyl-3-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [S-(R*,R*)]- (9CI) | | CAS: | 135383-54-9 | | MF: | C20H29NO5 | | MW: | 363.45 | | EINECS: | | | Product Categories: | | | Mol File: | 135383-54-9.mol |  |
| | OBDXBUWPBDVKEB-KSSFIOAISA-N Chemical Properties |
| Boiling point | 476.6±35.0 °C(Predicted) | | density | 1.088±0.06 g/cm3(Predicted) | | pka | 10.13±0.46(Predicted) |
| | OBDXBUWPBDVKEB-KSSFIOAISA-N Usage And Synthesis |
| Uses | Monomethyl auristatin E intermediate-6 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. | | References | [1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931 |
| | OBDXBUWPBDVKEB-KSSFIOAISA-N Preparation Products And Raw materials |
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