| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:hiCE inhibitor-1
CAS:2654-68-4
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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| Company Name: |
LIFE CHEMICALS, formerly I.F. Lab
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| Tel: |
1 905 634 5212 |
| Email: |
vasily.pinchuk@lifechemicals.com |
| Products Intro: |
Product Name:N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide)
CAS:2654-68-4
Purity:90%+ Package:100mg
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N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) manufacturers
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| | N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Basic information |
| | N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Chemical Properties |
| Melting point | 272 °C | | Boiling point | 615.8±65.0 °C(Predicted) | | density | 1.568±0.06 g/cm3(Predicted) | | pka | 7.41±0.10(Predicted) |
| | N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Usage And Synthesis |
| Uses | hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1]. | | References | [1] Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43. DOI:10.1124/mol.65.6.1336 |
| | N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Preparation Products And Raw materials |
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