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| | (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Basic information |
| | (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Chemical Properties |
| Boiling point | 120-122°C 0,5mm | | density | 1.076 | | Fp | 143℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 9.37±0.29(Predicted) | | form | solid | | Appearance | Colorless to light yellow Viscous Liquid | | Optical Rotation | 0.15°(C=1 g/100ml MEOH) | | InChI | 1S/C12H18N2O/c13-8-12-10-14(6-7-15-12)9-11-4-2-1-3-5-11/h1-5,12H,6-10,13H2 | | InChIKey | CKZVBXBEDDAEFE-UHFFFAOYSA-N | | SMILES | NCC1OCCN(C1)CC2=CC=CC=C2 | | CAS DataBase Reference | 110859-47-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 34 | | Safety Statements | 26-36/37/39 | | RIDADR | 2735 | | Hazard Note | Irritant | | HS Code | 2921199990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (4-benzyl-2-morpholinyl)methanamine from 2-[[4-(benzyl)-2-morpholinyl]methyl]-1H-isoindole-1,3(2H)-dione: To a 50 mL single-necked round-bottomed flask was added 2-(4-benzylmorpholin-2-yl)methylphthalimide (1.3 g, 3.87 mmol) and hydrazine hydrate (0.38 g, 7.6 mmol) and ethanol (13 mL) was added. The mixture was heated to 80 °C and then stirred for 4 hours. After completion of the reaction, which was monitored by thin layer chromatography (TLC), the resulting solution was cooled to room temperature and filtered to separate the inorganic material. The filtrate was concentrated under vacuum, 10% sodium hydroxide solution (10 mL) was added and extracted twice with dichloromethane (20 mL). All extracted organic layers were combined, dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under vacuum to give a solid product. The resulting solid was dried in an oven at 60 °C to give (4-benzylmorpholin-2-yl)methylamine (550 mg, 69% yield). The dried product was used directly in the subsequent reaction. | | References | [1] Journal of Medicinal Chemistry, 1990, vol. 33, # 5, p. 1406 - 1413
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 10, p. 1356 - 1363
[3] Patent: WO2012/128582, 2012, A2. Location in patent: Page/Page column 110
[4] Patent: WO2007/71936, 2007, A1. Location in patent: Page/Page column 86 |
| | (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Preparation Products And Raw materials |
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