- 4-methoxypyridazine
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- $0.00 / 1KG
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2022-01-04
- CAS:20733-11-3
- Min. Order: 1g
- Purity: 98%minGC
- Supply Ability: 20kgs/month
- 4-METHOXYPYRIDAZINE
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- $1.10 / 1g
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2021-11-03
- CAS:20733-11-3
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 4-METHOXYPYRIDAZINE
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- $1.00 / 1KG
-
2019-09-06
- CAS:20733-11-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20tons
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| | 4-METHOXYPYRIDAZINE Basic information |
| Product Name: | 4-METHOXYPYRIDAZINE | | Synonyms: | 4-METHOXYPYRIDAZINE;4-Methoxy-pyridazin;4-methoxypyridazine hydrochloride;Pyridazine, 4-methoxy-;4-METHOXYPYRIDAZINE ISO 9001：2015 REACH | | CAS: | 20733-11-3 | | MF: | C5H6N2O | | MW: | 110.11 | | EINECS: | | | Product Categories: | | | Mol File: | 20733-11-3.mol |  |
| | 4-METHOXYPYRIDAZINE Chemical Properties |
| Melting point | 43-44℃ | | Boiling point | 244℃ | | density | 1.102 | | Fp | 89℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.28±0.10(Predicted) | | Appearance | Light yellow to yellow Solid | | InChI | InChI=1S/C5H6N2O/c1-8-5-2-3-6-7-4-5/h2-4H,1H3 | | InChIKey | NSGNREBTEFKPIL-UHFFFAOYSA-N | | SMILES | C1=NN=CC=C1OC |
| | 4-METHOXYPYRIDAZINE Usage And Synthesis |
| Uses | 4-methoxypyridazine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Uses | 
To a solution of 3 ,6-dichloro-4- methoxypyridazine (30 g, 167.59 mmol, 1.00 equiv) and ammonium formate (3 1 g, 491.63 mmol, 2.93 equiv) in MeOH (500 mL) was added 10% palladium on carbon (3 g) catalyst. The mixture was stirred under 1 atmosphere of at rt overnight. The catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was triturated in 500 mL of DCM MeOH ( 10: 1 ) and the solid material was filtered out. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (2:1 to 1: 1) to give 1 5 g (81%) of 4-methoxypyridazine as a brown oil. TLC: petroleum ether: ethyl acetate=2: 1 , Rf=0.1 . | | Synthesis | General procedure for the synthesis of 4-methoxypyridazine from 4-methoxy-3,6-dichloropyridazine: 10% palladium carbon (3 g) catalyst was added to a solution of methanol (500 mL) containing 3,6-dichloro-4-methoxypyridazine (30 g, 167.59 mmol, 1.00 equiv) and ammonium formate (31 g, 491.63 mmol, 2.93 equiv). The reaction mixture was stirred at room temperature and 1 atm overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. The concentrated residue was ground in a solvent mixture of dichloromethane and methanol (500 mL, 10:1 v/v) and subsequently filtered to collect the solid. The filtrate was again concentrated under vacuum and the residue was purified by silica gel column chromatography with the eluent being a solvent mixture of ethyl acetate and petroleum ether (the ratio was tapered from 2:1 to 1:1), resulting in 15 g (81% yield) of 4-methoxypyridazine as a brown oil. Thin-layer chromatography (TLC) conditions: the ratio of petroleum ether to ethyl acetate was 2:1, and the Rf value was 0.1. | | References | [1] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 99
[2] Helvetica Chimica Acta, 1956, vol. 39, p. 1755,1762 |
| | 4-METHOXYPYRIDAZINE Preparation Products And Raw materials |
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