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N-Formylglycine

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CAS:2491-15-8
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CAS:2491-15-8
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CAS:2491-15-8
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CAS:2491-15-8
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N-Formylglycine manufacturers

  • N-Formylglycine
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  • $39.00 / 500mg
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  • CAS:2491-15-8
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  • Purity: 99.79%
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  • 2021-08-12
  • CAS:2491-15-8
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  • N-Formylglycine
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  • $1.00 / 1KG
  • 2019-09-02
  • CAS:2491-15-8
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N-Formylglycine Basic information
Product Name:N-Formylglycine
Synonyms:Formylglycin;N-FORMYLGLYCINE 98+%;2-formamidoacetic acid;2-formamidoethanoic acid;N-Formylglycine >=98.0%;N-Formylglycine;N-For-Gly-OH;N-ALPHA-FORMYL-GLYCINE
CAS:2491-15-8
MF:C3H5NO3
MW:103.08
EINECS:219-649-8
Product Categories:Amino Acid Derivatives;Glycine;Peptide Synthesis
Mol File:2491-15-8.mol
N-Formylglycine Structure
N-Formylglycine Chemical Properties
Melting point 149-151 °C
Boiling point 193.26°C (rough estimate)
density 1.4873 (rough estimate)
refractive index 1.4940 (estimate)
storage temp. 2-8°C
solubility Methanol (Slightly), Water (Slightly)
pkapK1:3.43 (25°C)
form Solid
color White
Water Solubility very faint turbidity
BRN 1749108
Major Applicationpeptide synthesis
InChI1S/C3H5NO3/c5-2-4-1-3(6)7/h2H,1H2,(H,4,5)(H,6,7)
InChIKeyUGJBHEZMOKVTIM-UHFFFAOYSA-N
SMILESOC(=O)CNC=O
CAS DataBase Reference2491-15-8(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS MC0547000
HS Code 29241990
Storage Class11 - Combustible Solids
ToxicityLD50 unreported in rat: > 3gm/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
N-Formylglycine Usage And Synthesis
Chemical PropertiesWhite solid
UsesN-Formylglycine is a simple dipeptide and a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.
DefinitionChEBI: An N-acylglycine resulting from the formal condensation of the amino group of glycine with formic acid.
reaction suitabilityreaction type: solution phase peptide synthesis
Synthesis
Formic acid

64-18-6

Glycine

56-40-6

N-Formylglycine

2491-15-8

The general procedure for the synthesis of 2-formamidoacetic acid from formic acid and glycine was as follows: formic acid (140 mL, 3.71 mol) was reacted with acetic anhydride (47 mL, 0.50 mol) with stirring for 1 hour at 45 °C. Subsequently, glycine (0.05 mol) was added to the reaction mixture and stirring was continued at room temperature for 24 hours. After completion of the reaction, the mixture was evaporated to dryness to afford the target product 2-formamidoacetic acid.

References[1] Organic and Biomolecular Chemistry, 2015, vol. 14, # 1, p. 93 - 96
[2] Synthetic Communications, 1983, vol. 13, # 9, p. 745 - 752
[3] Organic Letters, 2018, vol. 20, # 18, p. 5877 - 5880
[4] Chemical Communications, 2012, vol. 48, # 31, p. 3775 - 3777
[5] Tetrahedron, 2013, vol. 69, # 43, p. 9161 - 9165
N-Formylglycine Preparation Products And Raw materials
Raw materialsFormic acid-->formamide-->Glycine
Preparation Products2-Hydroxypropanoic acid-->4-Pyrimidinol-->2,4-Diaminopyrimidine-->Glycolic acid
Tag:N-Formylglycine(2491-15-8) Related Product Information
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