| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:Trolline((±)-Trolline)
CAS:1021950-79-7
Purity:HPLC>=98% Package:5mg;10mg;20mg;50mg;100mg;200mg;500mg;1g
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| | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Basic information |
| Product Name: | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE | | Synonyms: | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE;Trolline((±)-Trolline);Trolline;Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy-;Oleracein E | | CAS: | 1021950-79-7 | | MF: | C12H13NO3 | | MW: | 219.24 | | EINECS: | | | Product Categories: | | | Mol File: | 1021950-79-7.mol | ![8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Structure](CAS/20180528/GIF/1021950-79-7.gif) |
| | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Chemical Properties |
| | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Usage And Synthesis |
| Description | Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation. | | Uses | (±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis[1]. | | References | [1] Bai F, et, al. Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy. Cell Physiol Biochem. 2017;44(2):436-446. DOI:10.1159/000485009 |
| | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Preparation Products And Raw materials |
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