- 1,3,5-Trimethoxybenzene
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- $0.00 / 25kg
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2026-01-04
- CAS:621-23-8
- Min. Order: 1kg
- Purity: 99.0%min
- Supply Ability: 10000kg
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| | 1,3,5-Trimethoxybenzene Basic information |
| Product Name: | 1,3,5-Trimethoxybenzene | | Synonyms: | 1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;PHLOROGLUCINOL TRIMETHYL ETHER;TRISMETHOXYBENZENE;1,3,5-TriMethoxybenzene ReagentPlus(R), >=99%;1,3,5-Methoxybenzene;1,3,5-TriMetho;1,3,5-trimethoxy-benzen;1,3,5-Trimethyoxybenzene | | CAS: | 621-23-8 | | MF: | C9H12O3 | | MW: | 168.19 | | EINECS: | 210-673-4 | | Product Categories: | Benzene derivates;Aromatic Ethers;ACTIVE PHARMACEUTICAL INGREDIENTS;621-23-8;API | | Mol File: | 621-23-8.mol |  |
| | 1,3,5-Trimethoxybenzene Chemical Properties |
| Melting point | 50-53 °C (lit.) | | Boiling point | 255 °C (lit.) | | density | 1,126g/cm | | refractive index | 1,533 | | Fp | 186 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | methanol: 0.1 g/mL, clear, colorless | | form | Crystalline Powder | | color | White to cream | | Water Solubility | insoluble | | BRN | 1307993 | | Cosmetics Ingredients Functions | SKIN CONDITIONING | | InChIKey | LKUDPHPHKOZXCD-UHFFFAOYSA-N | | LogP | 1.605 (est) | | CAS DataBase Reference | 621-23-8(CAS DataBase Reference) | | NIST Chemistry Reference | 1,3,5-Trimethoxybenzene(621-23-8) | | EPA Substance Registry System | 1,3,5-Trimethoxybenzene (621-23-8) |
| Hazard Codes | Xn,F | | Risk Statements | 22-20/21/22 | | Safety Statements | 24/25-36-26 | | RIDADR | 1325 | | WGK Germany | 3 | | RTECS | DC2810000 | | Hazard Note | Flammable Solid/Harmful | | TSCA | TSCA listed | | HazardClass | 4.1 | | PackingGroup | III | | HS Code | 29093090 |
| | 1,3,5-Trimethoxybenzene Usage And Synthesis |
| Chemical Properties | white to cream crystalline powder. Insoluble in water. | | Uses | 1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes. | | Definition | ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite. | | Reactions | 1,3,5-Trimethoxybenzene is the main component of the Leaf Oil of Eugenia confusa and is also a commonly used chemical reagent in organic synthesis. It can be used in the following reactions:
(1) Friedel–Crafts reaction: In this reaction, 4,5-dichlorocyclopent-4-ene-1,3-dione reacts with 1,3,5-trimethoxybenzene to synthesize 5-(2,4,6-trimethoxyphenyl)-4-chlorocyclopent-4-ene-1,3-dione, and also generates the disubstituted product 3,4-bis-(2,4,6-trimethoxyphenyl)-2-chlorocyclopent-2-ene-1-one[1].
(2) Addition reaction: Using trifluoromethanesulfonic acid as a catalyst, 1,3,5-trimethoxybenzene can react with maleimide to undergo a 1,4-addition reaction to synthesize 3-(2,4,6-trimethoxyphenyl) succinimide. It can also undergo a 1,4-addition reaction with acrylates[2].
(3) Nitration reaction: 1,3,5-Trimethoxybenzene can be nitrated with N2O5 in an organic solvent to prepare 1,3,5-trimethoxy-2,4,6-trinitrobenzene. However, this method is not very practical due to the side reactions of oxidation and coupling[3]. | | General Description | 1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species. | | Synthesis | A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).
 | | Solubility in organics | Soluble in Methanol, Ether, Ethanol, Benzene. | | Solubility in water | Insoluble | | Purification Methods | Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.] | | References | [1] V. A. EGOROV. Double Acylation Product in the SnCl4-promoted Reaction of 4,5-Dichlorocyclopent-4-en-1,3-dione with 1,3,5-Trimethoxybenzene[J]. Russian Journal of Organic Chemistry, 2023, 59 8: 1449-1452. DOI:10.1134/S1070428023080201.
[2] SEANGHAI HOR . Br?nsted acid-catalyzed 1,4-addition of 1,3,5-trimethoxybenzene to maleimides and acrylates[J]. Tetrahedron Letters, 2021, 74: Article 153100. DOI:10.1016/j.tetlet.2021.153100.
[3] A. J. BELLAMY. Nitration of 1,3,5-Trimethoxybenzene[J]. Journal of Chemical Research-s, 2002, 109 3 1: 412-413. DOI:10.3184/030823402103172662. |
| | 1,3,5-Trimethoxybenzene Preparation Products And Raw materials |
| Raw materials | 3,5-Dibromoanisole-->1-Bromo-3,5-dimethoxybenzene-->Sodium Methoxide-->1,3,5-Tribromobenzene | | Preparation Products | P276-->dracorhodin-->2',4',6'-TRIMETHOXYACETOPHENONE-->1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE |
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