- Homobutein
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- $98.00 / 1mg
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2026-02-02
- CAS:34000-39-0
- Min. Order:
- Purity: 99.50%
- Supply Ability: 10g
- HOMOBUTEIN
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- $302.00 / 100KG
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2019-07-06
- CAS:34000-39-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000kg
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| | HOMOBUTEIN Basic information |
| Product Name: | HOMOBUTEIN | | Synonyms: | HOMOBUTEIN;(E)-2',4,4'-trihydroxy-3-methoxychalcone;3-O-methylbutein;HOMOBUTEIN WITH HPLC;HOMOBUTEIN hplc;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one;4,2',4'-Trihydroxy-3-methoxychalcone;Einecs 251-782-7 | | CAS: | 34000-39-0 | | MF: | C16H14O5 | | MW: | 286.28 | | EINECS: | 251-782-7 | | Product Categories: | Chalcones | | Mol File: | 34000-39-0.mol |  |
| | HOMOBUTEIN Chemical Properties |
| Melting point | 207-212°C | | Boiling point | 523.8±50.0 °C(Predicted) | | density | 1.369±0.06 g/cm3(Predicted) | | form | Solid | | pka | 7.43±0.35(Predicted) | | color | Light yellow to yellow | | LogP | 2.880 (est) |
| | HOMOBUTEIN Usage And Synthesis |
| Uses | Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4]. | | Definition | ChEBI: Homobutein is a member of chalcones. | | IC 50 | Toxoplasma | | References | [1] Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. DOI:10.3892/or.2012.1870
[2] Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383. PMID:31543702
[3] Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32. DOI:10.1016/j.phytochem.2004.08.050
[4] Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90. |
| | HOMOBUTEIN Preparation Products And Raw materials |
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