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| | Gigavlkvlttglpaliswikrkrq-OH Basic information |
| Product Name: | Gigavlkvlttglpaliswikrkrq-OH | | Synonyms: | MELITTIN;MELITTIN (FREE ACID);GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN: GIGAVLKVLTTGLPALISWIKRKRQQ;Melittin trifluoroacetate;Gigavlkvlttglpaliswikrkrq-OH | | CAS: | 123168-46-7 | | MF: | C131H228N38O32 | | MW: | 2847.45 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | Gigavlkvlttglpaliswikrkrq-OH Chemical Properties |
| | Gigavlkvlttglpaliswikrkrq-OH Usage And Synthesis |
| Uses | Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2]. | | in vivo | Melittin (intraperitoneal inoculation) increases 13,14-dihydro-15-keto-PGE2 levels in peripheral blood of mice[1]. | | References | [1] Hassid A, Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977. PMID:928951
[2] Memariani H, Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526. DOI:10.1007/s00253-020-10701-0 |
| | Gigavlkvlttglpaliswikrkrq-OH Preparation Products And Raw materials |
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