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5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine manufacturers
- CBFβ Inhibitor
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- $29.00
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2026-08-04
- CAS:493028-20-9
- Purity: 97.02%
- Supply Ability: 10g
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| | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine Basic information |
| Product Name: | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine | | Synonyms: | TIMTEC-BB SBB011699;CBFβ Inhibitor;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;Runx1-CBFβ interaction inhibitor 1;CBFβInhibitor;5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine | | CAS: | 493028-20-9 | | MF: | C12H14N2OS | | MW: | 234.32 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine Chemical Properties |
| Boiling point | 421.6±40.0 °C(Predicted) | | density | 1.192±0.06 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml | | form | Tan solid | | pka | 5.00±0.10(Predicted) |
| Hazard Codes | Xi | | HazardClass | IRRITANT |
| | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine Usage And Synthesis |
| Description | Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity. | | Uses | Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity. | | References | [1] KEVIN A. LINK James C M Fu Sheng Chou. Core binding factor at the crossroads: Determining the fate of the HSC[J]. Journal of Cellular Physiology, 2009, 222 1: 50-56. DOI: 10.1002/jcp.21950
[2] GEMMA SWIERS Nancy A S Marella de Bruijn. Hematopoietic stem cell emergence in the conceptus and the role of Runx1.[J]. International Journal of Developmental Biology, 2010, 54 6-7: 1151-1163. DOI: 10.1387/ijdb.103106gs
[3] MICHAEL J GORCZYNSKI. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.[J]. Chemistry & biology, 2007, 14 10: 1186-1197. DOI: 10.1016/j.chembiol.2007.09.006 |
| | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine Preparation Products And Raw materials |
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