2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:2-BFI hydrochloride
CAS:89196-95-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:2-BFI hydrochloride
CAS:89196-95-2
Purity:100% Package:5mg;32USD|10mg;52USD|25mg;110USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
CAS:89196-95-2
Purity:95.0% windy 810
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Products Intro: Product Name:2-BFI hydrochloride
CAS:89196-95-2
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Company Name: Chemtour Biotech Co., Ltd
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Products Intro: Product Name:2-BFI(HCl)
CAS:89196-95-2
Purity:99% Package:5KG;1KG

2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE manufacturers
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Basic information
Product Name:2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
Synonyms:2-BFI HCL;2-BFI HYDROCHLORIDE;2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE;2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride;2-BFI hydrochlorid (2 BFI hydrochloride;2BFI hydrochloride,2 BFI hydrochloride;RX 801077 hydrochloride;2-(Benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
CAS:89196-95-2
MF:C11H11ClN2O
MW:222.67
EINECS:
Product Categories:Imidazoline binding site
Mol File:89196-95-2.mol
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Structure
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Chemical Properties
storage temp. Desiccate at RT
solubility DMSO: 20mg/mL, clear
form White powder.
color White to off-white
Water Solubility Soluble to 100 mM in water
InChI1S/C11H10N2O.ClH/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11;/h1-4,7H,5-6H2,(H,12,13);1H
InChIKeyRFNFFVDVGWOSNZ-UHFFFAOYSA-N
SMILES[H]Cl.C12=CC=CC=C1OC(C3=NCCN3)=C2
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
MSDS Information
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Usage And Synthesis
Uses2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride is a I2 receptor agonists that induces hypothermic effect in rats.
Biological ActivityHigh affinity I 2 ligand (K i = 9.8 nM). Putative I 2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
in vivo

RX 801077 hydrochloride (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].

Animal Model:280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
Dosage:5, 10, 20 mg/kg
Administration:I.p.; twice daily for 3 days
Result:Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
storageDesiccate at RT
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE Preparation Products And Raw materials
Tag:2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE(89196-95-2) Related Product Information
2-Benzofurancarboxamidine 2-FURANCARBOXIMIDAMIDE ETHYL-FURAN-2-YLMETHYL-AMINE BENZOFURAN-2-YLMETHANAMINE 2-FURAN-2-YL-4,5-DIHYDRO-1H-IMIDAZOLE 2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE 2-FURANCARBOXIMIDAMIDE HCL 1-BENZOFURAN-2-YL-N-METHYLMETHANAMINE