- Pantoprazole sodium
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- $42.00 / 100mg
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2026-01-20
- CAS:138786-67-1
- Min. Order:
- Purity: 99.81%
- Supply Ability: 10g
- Pantoprazole Sodium
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- $1.00 / 1KG
-
2026-01-20
- CAS:138786-67-1
- Min. Order: 1KG
- Purity: 99.0%~101.0%,EP9.0
- Supply Ability: 1000kg/month
- Pantoprazole Sodium
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- $460.00 / 1Kg/Bag
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2025-12-03
- CAS:138786-67-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1T
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| | Pantoprazole Sodium Basic information |
| | Pantoprazole Sodium Chemical Properties |
| Melting point | 199-202°C | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly) | | form | Solid | | color | White to Pale Beige | | Stability: | Hygroscopic | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1 | | InChIKey | YNWDKZIIWCEDEE-UHFFFAOYSA-N | | SMILES | C12C=C(C=CC=1N(C(S(=O)CC1N=CC=C(OC)C=1OC)=N2)[Na])OC(F)F | | CAS DataBase Reference | 138786-67-1(CAS DataBase Reference) | | CAS Number Unlabeled | 138786-67-1 |
| | Pantoprazole Sodium Usage And Synthesis |
| Chemical Properties | White to Off-White Solid | | Originator | Controloc,Byk Gulden ,Germany | | Uses | Gastrointestinal | | Uses | An antiulcerative. Gastric pump inhibitor. | | Definition | ChEBI: Pantoprazole sodium is an organic sodium salt. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It contains a pantoprazole(1-). | | Manufacturing Process | 2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added,
whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%. | | Brand name | Protonix (Wyeth). | | Therapeutic Function | Antiulcer | | General Description | Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion. | | Biological Activity | Gastric proton pump inhibitor. It is used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | | References | [1] Patent: WO2004/111029, 2004, A2. Location in patent: Page 24
[2] Patent: CN107011252, 2017, A. Location in patent: Paragraph 0101; 0103
[3] Patent: WO2004/111029, 2004, A2. Location in patent: Page 24
[4] Patent: WO2009/75516, 2009, A2. Location in patent: Page/Page column 5
[5] Patent: WO2004/111029, 2004, A2. Location in patent: Page 24 |
| | Pantoprazole Sodium Preparation Products And Raw materials |
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