- 3-Chloro-6-methylpyridazine
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- $200.00 / 1KG
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2025-09-25
- CAS:1121-79-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 3-Chloro-6-methylpyridazine Basic information |
| | 3-Chloro-6-methylpyridazine Chemical Properties |
| Melting point | 58-62 °C | | Boiling point | 58 °C | | density | 1.234±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO, Methanol (Slightly) | | form | Solid | | pka | 1.26±0.10(Predicted) | | color | Pale Beige | | BRN | 108655 | | InChI | InChI=1S/C5H5ClN2/c1-4-2-3-5(6)8-7-4/h2-3H,1H3 | | InChIKey | PRORLQAJNJMGAR-UHFFFAOYSA-N | | SMILES | C1(Cl)=NN=C(C)C=C1 | | CAS DataBase Reference | 1121-79-5(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38-43-41-38-22 | | Safety Statements | 26-37/39-36/37-37 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1 |
| Provider | Language |
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ALFA
| English |
| | 3-Chloro-6-methylpyridazine Usage And Synthesis |
| Chemical Properties | colorless to yellow liquid | | Uses | 3-Chloro-6-methylpyridazine is used for preparation of heterocyclic compounds as integrase inhibiting antiviral agents. | | Reactions | 3-Chloro-6-methyl pyridazine can undergo nickel catalyzed cross coupling reaction with aromatic and heteroaromatic halides, to give the corresponding substituted aryl- and heteroaryl pyridazines. | | Definition | ChEBI: 3-Chloro-6-methylpyridazine is a member of pyridazines. | | Pharmaceutical Applications | 3-Chloro-6-methylpyridazine can be used in the synthesis of a p38MAP kinase inhibitor with
therapeutic potential in the treatment of autoimmune and inflammatory
diseases. | | Synthesis | Add 6-methyl-3(2H)-pyridazinone and chlorinating agent to the reaction vessel; POCl₃ can act as solvent if used. Heat to 80–120℃, reflux for 2–6 hours to substitute the hydroxyl group of pyridazinone with chlorine. After reaction, slowly pour the solution into ice water to quench excess chlorinating agent, adjust pH to neutral with sodium carbonate or sodium hydroxide. Extract with dichloromethane, ethyl acetate, etc., dry the extract with anhydrous sodium sulfate, remove solvent by reduced pressure distillation to get crude product. Purify via recrystallization (e.g., ethanol-water solvent) or column chromatography to obtain high-purity 3-chloro-6-methylpyridazine. |
| | 3-Chloro-6-methylpyridazine Preparation Products And Raw materials |
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