2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE manufacturers
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| | 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Basic information |
| | 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol | | form | White solid. | | color | White to off-white |
| | 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Usage And Synthesis |
| Uses | Opioid agonists exert a broad range of effects on the immune system ranging from inflammatory response modulation to opioid and chemokine receptor expression. ICI 199441 is a selective κ-opioid agonist with analgesic properties. | | Biological Activity | Highly potent κ agonist, 146-fold more active than U-50488 (trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride ) in vitro . | | in vivo | ICI 199441 (Wistar rats, 0.1 mg/kg, IV, once) administered 15 min before ischemia produces a potent antiarrhythmic effect[1]. | | IC 50 | κ Opioid Receptor/KOR | | storage | Store at RT |
| | 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Preparation Products And Raw materials |
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