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| | 6-Methylnicotinaldehyde Chemical Properties |
| Boiling point | 95℃/20mm | | density | 1.084 | | refractive index | 1.546 | | Fp | 88℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 4.15±0.10(Predicted) | | form | Liquid | | Appearance | Colorless to light yellow Liquid | | Sensitive | Moisture Sensitive | | InChI | InChI=1S/C7H7NO/c1-6-2-3-7(5-9)4-8-6/h2-5H,1H3 | | InChIKey | IMWMEIWYPWVABQ-UHFFFAOYSA-N | | SMILES | C1=NC(C)=CC=C1C=O | | CAS DataBase Reference | 53014-84-9 |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 29333990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | 6-Methylnicotinaldehyde Usage And Synthesis |
| Application | 3-Aldehyde-6-methylpyridine is a pyridine heterocyclic compound mainly used in laboratory research and development of organic synthesis processes. | | Synthesis | To a solution of 5-bromo-2-methylpyridine (151; 10 g, 58.1 mmol) in THF (150 mL) was added n-BuLi (2.5 M, 25.6 mL) at -78 ℃. The reaction mixture was stirred at this temperature for Ih. DMF (1.30 mL) was added,, and the resulting reaction mixture was stirred for 1 h at -78 °C. The addition of aq quenched the reaction. NH4Cl. Upon warming to room temperature, the mixture was extracted with EtOAc. The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure. The resulting residue was purified by chromatography to afford 6-methylnicotinaldehyde 152 (5.0 g, 72percent). | | References | [1] Patent: US2006/287341, 2006, A1. Location in patent: Page/Page column 46
[2] Patent: US2007/4772, 2007, A1. Location in patent: Page/Page column 82
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 3, p. 583 - 593
[4] Journal of Organic Chemistry, 1988, vol. 53, # 15, p. 3513 - 3521
[5] Patent: US4778796, 1988, A |
| | 6-Methylnicotinaldehyde Preparation Products And Raw materials |
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