| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | Benzofuran-3-carbaldehyde Basic information |
| Product Name: | Benzofuran-3-carbaldehyde | | Synonyms: | RARECHEM AK ML 0128;3-Benzofurancarbaldehyde;1-Benzofuran-3-carbaldehyde;3-Benzofurancarboxaldehyde;Benzofuran-3-carboxaldehyde;3-Formylbenzo[b]furan;BENZOFURAN-3-CARBALDEHYDE, 10 mM in DMSO;Benzofuran-3-carbaldehyde | | CAS: | 4687-25-6 | | MF: | C9H6O2 | | MW: | 146.14 | | EINECS: | | | Product Categories: | API intermediate | | Mol File: | 4687-25-6.mol |  |
| | Benzofuran-3-carbaldehyde Chemical Properties |
| Melting point | 39℃ (ligroine ) | | Boiling point | 165℃ (18 Torr) | | density | 1.238±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | Solid | | color | White to yellow |
| | Benzofuran-3-carbaldehyde Usage And Synthesis |
| Uses | Benzofuran-3-carbaldehyde is a bioactive chemical, and can be used for the synthesis of active compound[1]. | | Synthesis | The general procedure for the synthesis of 3-formylbenzofuran from 3-methylbenzofuran was as follows: 3-methylbenzofuran (200 mg, 0.19 mL, 1.5 mmol) and selenium dioxide (SeO2, 200 mg, 1.8 mmol, 1.2 eq.) were suspended in 1,4-dioxane (3 mL) and heated and refluxed for 24 hours. Upon completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with ethyl acetate/hexane (2:1 v/v, 10 mL), and filtered through a short silica gel plug to remove the selenium residue. The silica gel plugs were washed with ethyl acetate (2 x 3 mL), and the organic filtrates were combined and evaporated to dryness. Purification by silica gel column chromatography (eluent: hexane/ethyl acetate 96:4) afforded the yellow oily product 3-formylbenzofuran (162 mg, 1.1 mmol, 74% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 10.18 (s, 1H), 8.26 (s, 1H), 8.19 (m, 1H), 7.54 (m, 1H), 7.41 (m, 2H); ESI-MS m/z = 147.0 ([MH]+), calculated value C9H7O2 = 147.04. | | References | [1] Bolling BW, et al. Phenolic derivatives from soy flour ethanol extract are potent in vitro quinone reductase (QR) inducing agents. J Agric Food Chem. 2008 Nov 26;56(22):10473-80. DOI:10.1021/jf801541t |
| | Benzofuran-3-carbaldehyde Preparation Products And Raw materials |
|