|
|
| | 5-Nitro-benzo[b]thiophene-2-carboxylic acid methyl ester Basic information |
| Product Name: | 5-Nitro-benzo[b]thiophene-2-carboxylic acid methyl ester | | Synonyms: | METHYL 5-NITRO-1-BENZOTHIOPHENE-2-CARBOXYLATE;BUTTPARK 48\04-47;5-Nitro-1-benzothiophene-2-carboxylic acid methyl ester;5-Nitrothionaphthene-2-carboxylic acid methyl ester;Methyl 5-nitrobenzo[b]thiophene-2-carboxylate;5-nitrobenzo[b]thiophene-2-carboxylate;Benzo[b]thiophene-2-carboxylic acid, 5-nitro-, methyl ester;methyl 5-nitrobenzothiophene-2-carboxylate | | CAS: | 20699-86-9 | | MF: | C10H7NO4S | | MW: | 237.23 | | EINECS: | | | Product Categories: | | | Mol File: | 20699-86-9.mol | ![5-Nitro-benzo[b]thiophene-2-carboxylic acid methyl ester Structure](CAS/GIF/20699-86-9.gif) |
| | 5-Nitro-benzo[b]thiophene-2-carboxylic acid methyl ester Chemical Properties |
| Melting point | 199-200 °C | | Boiling point | 393.2±22.0 °C(Predicted) | | density | 1.457±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | Appearance | Light yellow to yellow Solid | | CAS DataBase Reference | 20699-86-9 |
| | 5-Nitro-benzo[b]thiophene-2-carboxylic acid methyl ester Usage And Synthesis |
| Synthesis | General procedure for the synthesis of methyl 5-nitrobenzo[b]thiophene-2-carboxylate from methyl mercaptoacetate and 2-chloro-5-nitrobenzaldehyde: To a solution of 2-chloro-5-nitrobenzaldehyde (3.7 g, 0.020 mol) in N,N-dimethylformamide (40 mL) was added methyl mercaptoacetate (1.82 mL, 0.020 mol), followed by potassium carbonate ( 3.3 g, 0.024 mol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, water was added to the mixture and the suspension was filtered. The solid residue was washed with water to afford the target product methyl 5-nitrobenzo[b]thiophene-2-carboxylate as a yellow solid. Yield: 95%. | | References | [1] Synthetic Communications, 1991, vol. 21, # 7, p. 959 - 964
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 24, p. 6814 - 6824
[3] Patent: WO2006/101454, 2006, A1. Location in patent: Page/Page column 45
[4] Patent: EP2876105, 2015, A1. Location in patent: Paragraph 0945; 0946
[5] Heterocycles, 2008, vol. 75, # 8, p. 1913 - 1929 |
| | 5-Nitro-benzo[b]thiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials |
|