2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride

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2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride manufacturers
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Basic information
Product Name:2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride
Synonyms:2-(2-(6-chlorohexyloxy)ethoxy)ethanamine HCl;2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride;2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride;2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylammonium hydrochloride;Cl-C6-PEG2-NH2 hydrochloride;Cl-C6-PEG2-NH2 (HCl salt);2-[2-(6-chlorohexoxy)ethoxy]ethanamine;NH2-PEG2-C6-Cl hydrochloride
CAS:1035373-85-3
MF:C10H23Cl2NO2
MW:260.2
EINECS:
Product Categories:
Mol File:1035373-85-3.mol
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Structure
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Chemical Properties
storage temp. -20°C, sealed storage, away from moisture
form Solid
color White to yellow
InChIInChI=1S/C10H22ClNO2.ClH/c11-5-3-1-2-4-7-13-9-10-14-8-6-12;/h1-10,12H2;1H
InChIKeyKRGPBUVQAULFOQ-UHFFFAOYSA-N
SMILESC(CCCCCCl)OCCOCCN.Cl
Safety Information
MSDS Information
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Usage And Synthesis
Uses2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50PEGs
References[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Preparation Products And Raw materials
Tag:2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride(1035373-85-3) Related Product Information
Ethanamine, 2-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]-, hydrochloride (1:1) 21-Chloro-3,6,9,12,15-pentaoxahenicosan-1-amine hydrochloride 2-((6-Chlorohexyl)oxy)ethan-1-ol Halo-PEG(4)-NH2*HCl Ethanamine, 2-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]- NH2-PEG5-C6-Cl