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| | Peimisine hydrochloride Basic information |
| Product Name: | Peimisine hydrochloride | | Synonyms: | Peimisine hydrochloride;(2'R,3S,3'R,3'aS,4aS,6'S,6aR,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',4a,5',6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-5(6H)-one, monohydrochloride | | CAS: | 900498-44-4 | | MF: | C27H41NO3.ClH | | MW: | 464.08 | | EINECS: | | | Product Categories: | | | Mol File: | 900498-44-4.mol |  |
| | Peimisine hydrochloride Chemical Properties |
| Melting point | 257 °C | | storage temp. | Store at -20°C | | solubility | DMSO: 16 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): Partially soluble | | form | A crystalline solid |
| | Peimisine hydrochloride Usage And Synthesis |
| Description | Peimisine HCl is a steroidal alkaloid that inhibits lung acetylcholinesterase (AChE). | | Uses | Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research[1][2][3]. | | References | [1] Pan F, et al. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis. Phytomedicine. 2014 Jul-Aug;21(8-9):1104-9. DOI:10.1016/j.phymed.2014.04.010
[2] Armando Alberola-Die, et al. Peimine, an Anti-Inflammatory Compound from Chinese Herbal Extracts, Modulates Muscle-Type Nicotinic Receptors. Int J Mol Sci. 2021 Oct 19;22(20):11287. DOI:10.3390/ijms222011287
[3] Dongdong Wang, et al. Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action. BMC Complement Altern Med. 2015 Feb 21;15:29. DOI:10.1186/s12906-015-0551-5 |
| | Peimisine hydrochloride Preparation Products And Raw materials |
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