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BOC Sciences |
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| Product Name: | ABD459 | | Synonyms: | ABD459;[5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-(4-methoxyphenyl)-methanone;ABD459,ABD-459;Methanone, [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl](4-methoxyphenyl)-;5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl](4-methoxyphenyl)-methanone | | CAS: | 1047670-51-8 | | MF: | C24H17BrCl2N2O2 | | MW: | 516.21 | | EINECS: | | | Product Categories: | | | Mol File: | 1047670-51-8.mol |  |
| | ABD459 Chemical Properties |
| Boiling point | 615.6±55.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 3 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml | | form | A crystalline solid | | pka | -3.35±0.10(Predicted) |
| | ABD459 Usage And Synthesis |
| Description | ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). It inhibits food consumption in nonfasted mice without affecting motor activity. ABD459 reduces active food seeking for 5-6 hours after treatment, with no rebound after washout. ABD459 also diminishes rapid eye movement (REM) sleep, with no alterations of wakefulness or non-REM sleep. | | Uses | ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders[1]. | | References | [1] Goonawardena AV, et al. Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459. Behav Pharmacol. 2015 Apr;26(3):289-303. DOI:10.1097/FBP.0000000000000108 |
| | ABD459 Preparation Products And Raw materials |
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