MIV-150
| 中文名称 | MIV-150 |
|---|---|
| 中文同义词 | 化合物 T16081;化合物 MIV-150 |
| 英文名称 | MIV-150 |
| 英文同义词 | MIV-150;PC 815;1-(5-cyanopyridin-2-yl)-3-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-;MIV150,MIV 150;Urea, N-(5-cyano-2-pyridinyl)-N'-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]- |
| CAS号 | 231957-54-3 |
| 分子式 | C19H17FN4O3 |
| 分子量 | 368.36 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 231957-54-3.mol |
| 结构式 |  |
MIV-150 性质
| 沸点 | 501.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：30mg/mL；二甲基亚砜：30mg/mL； DMSO:PBS(pH 7.2)(1:3)：0.25 mg/mL；乙醇：0.25mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 7.49±0.50(Predicted) |
|
HIV-1 <1 nM (EC 50 ) |
HIV-2 <1 nM (EC 50 ) |
The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC 50 of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC 50 of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150.