PKCiota-IN-49 manufacturers
- PKCiota-IN-2
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- $117.00
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2026-07-14
- CAS:2230055-52-2
- Purity: 99.74%
- Supply Ability: 10g
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| | PKCiota-IN-49 Basic information |
| Product Name: | PKCiota-IN-49 | | Synonyms: | PKCiota-IN-49;PKCiota-IN-2;Isoquinoline, 1,2,3,4-tetrahydro-6-methoxy-7-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-;6-methoxy-7-(5-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyrazolo[1,5-a]pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline;PKCiota-IN-2, 10 mM in DMSO | | CAS: | 2230055-52-2 | | MF: | C24H21N5O | | MW: | 395.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2230055-52-2.mol |  |
| | PKCiota-IN-49 Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | pka | 12.44±0.40(Predicted) |
| | PKCiota-IN-49 Usage And Synthesis |
| Uses | PKCiota-IN-2 (Compound 49) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively[1]. | | IC 50 | PKCι: 2.8 nM (IC50); PKCα: 71 nM (IC50); PKCε: 350 nM (IC50) | | References | [1] Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396. DOI:10.1021/acs.jmedchem.8b00060 |
| | PKCiota-IN-49 Preparation Products And Raw materials |
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