Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?-

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Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Suppliers list
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Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- manufacturers

  • S516
  • S516 pictures
  • $943.00
  • 2026-07-22
  • CAS:1016543-77-3
  • Purity: 97.44%
  • Supply Ability: 10g
Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Basic information
Product Name:Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?-
Synonyms:S516,S-516;Methanone, [4-(2-amino-4-thiazolyl)-2-(1H-1,2,4-triazol-1-yl)phenyl](3,4,5-trimethoxyphenyl)-;S516
CAS:1016543-77-3
MF:C21H19N5O4S
MW:437.47
EINECS:
Product Categories:
Mol File:1016543-77-3.mol
Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Structure
Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Chemical Properties
Boiling point 739.8±70.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 12.5 mg/mL (28.57 mM)
form Solid
pka3.75±0.10(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Usage And Synthesis
UsesS516 (Compound 22) is an active metabolite of CKD-516 and a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. S516 has marked antitumor activity[1].
in vivo

S516 (Compound 22; 5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) in human LX-1 lung cancer and CX-1 colon cancer mouse xenografts[1].

Animal Model:Mice bearing 3LL lung cancer[1]
Dosage:5 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection
Result:Had promising antitumor activity (inhibition ratio (IR)> 63%).
References[1] Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53(17):6337-54. DOI:10.1021/jm1002414
Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Preparation Products And Raw materials
Tag:Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?-(1016543-77-3) Related Product Information
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