PU139

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:PU139
CAS:158093-65-3
Purity:97.61% Package:1mg;56USD|5mg;122USD|10mg;213USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:PU-139
CAS:158093-65-3
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Shandong Lingqing Pharmaceutical Technology Co., Ltd.  Gold
Tel: 18668996177
Email: linkingpharm@126.com
Products Intro: Product Name:2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
CAS:158093-65-3
Purity:98% Package:50mg/RMB 3000
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:PU139
CAS:158093-65-3
Purity:98% Package:1mg;5mg;10mg
Company Name: Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd  
Tel: 0371-88900765 18037465274
Email: 3430974218@qq.com
Products Intro: Product Name:2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
CAS:158093-65-3
Purity:98.00% Package:1g;5g;10g;50g;100g

PU139 manufacturers

  • PU139
  • PU139 pictures
  • $48.00 / 1mg
  • 2026-04-20
  • CAS:158093-65-3
  • Min. Order:
  • Purity: 99.96%
  • Supply Ability: 10g
PU139 Basic information
Product Name:PU139
Synonyms:PU139;Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-fluorophenyl)-;2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
CAS:158093-65-3
MF:C12H7FN2OS
MW:246.26
EINECS:
Product Categories:API
Mol File:158093-65-3.mol
PU139 Structure
PU139 Chemical Properties
Boiling point 434.3±51.0 °C(Predicted)
density 1.473±0.06 g/cm3(Predicted)
storage temp. 4°C, away from moisture
solubility DMSO : 12.5 mg/mL (50.76 mM; ultrasonic and warming and heat to 60°C)
form Solid
pka0.43±0.20(Predicted)
color Off-white to yellow
Safety Information
MSDS Information
PU139 Usage And Synthesis
UsesPU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2].
Biological ActivityPU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2]. PU139 inhibits cell growth with GI50s of <60 μM (A431, A549, A2780, HepG2, SW480, U-87 MG, HCT116 and SK-N-SH and MCF7 cells)[1].PU139 (0-100 μM; 24-72 hours) triggers caspase-independent cell death in the neuroblastoma cell line SK-N-SH[1]. PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1].
in vivo

PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1].

Animal Model:Male NMRI:nu/nu mice (Neuroblastoma xenografts)[1]
Dosage:25 mg/kg
Administration:Intraperitoneally (PU139) with Dxorubicin at 8mg/kg i.v.; Administered on days 14 and 21 as a single dose of each compound or, for combination therapy; both drugs were administered successively within 1h.
Result:Optimum growth inhibition following a single PU139 therapy was moderate, but significant as compared with the untreated group and confirmed the previous findings.
IC 50GCN5: 8.39 μM (IC50); CREBBP: 2.49 μM (IC50); PCAF: 9.74 μM (IC50); p300: 5.35 μM (IC50)
References[1]. Gajer JM, et al. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015;4(2):e137. Published 2015 Feb 9. [2]. Carneiro VC, et al. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014;10(5):e1004116. Published 2014 May 8.
PU139 Preparation Products And Raw materials
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