- 2,6-Dichlorobenzylamine
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- $15.00 / 1KG
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2021-08-12
- CAS:6575-27-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 2,6-Dichlorobenzylamine Basic information |
| Product Name: | 2,6-Dichlorobenzylamine | | Synonyms: | SALOR-INT L480827-1EA;TIMTEC-BB SBB003780;RARECHEM AL BW 0148;2,6-DICHLOROBENZYLAMINE;(2,6-dichlorophenyl)methanamine;2,6-Dichlorobenzylamine, 97+%;2,6-Dichlorobenzylamine,98%;2,6-Dichlorobenzylamine ,99% | | CAS: | 6575-27-5 | | MF: | C7H7Cl2N | | MW: | 176.04 | | EINECS: | | | Product Categories: | Anilines, Aromatic Amines and Nitro Compounds | | Mol File: | 6575-27-5.mol |  |
| | 2,6-Dichlorobenzylamine Chemical Properties |
| Melting point | 40°C | | Boiling point | 108°C/ 8mm | | density | 1.320±0.06 g/cm3(Predicted) | | refractive index | 1.557-1.559 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 7.98±0.10(Predicted) | | form | Liquid | | color | Clear colorless to yellow | | Sensitive | Air Sensitive | | CAS DataBase Reference | 6575-27-5(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 45-36/37/39-26 | | RIDADR | UN2735 | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29214990 |
| Provider | Language |
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ACROS
| English |
| | 2,6-Dichlorobenzylamine Usage And Synthesis |
| Chemical Properties | Clear pale yellow liquid | | Uses | (2,6-Dichlorophenyl)methanamine was one of the reactants used in making a library of highly selective and potent G protein-coupled receptor kinase 2 inhibitors. | | Synthesis | The general procedure for the synthesis of 2,6-dichlorobenzaldehyde oxime as raw material for 2,6-dichlorobenzylamine was as follows: 2,6-dichlorobenzaldehyde oxime (0.121 g, 1 mmol) was mixed and milled with nano Fe3O4 (0.046 g, 0.2 mmol, particle size about 70 nm) in a porcelain mortar. Subsequently, ZrCl4 (0.233 g, 1 mmol) was added and the mixture continued to be ground at room temperature. The mortar was heated in an oil bath until the temperature of the reaction mixture reached 75-80 °C. After batchwise addition of NaBH3CN (0.314 g, 5 mmol), the reaction mixture was continued to be ground at 75-80 °C for 15 min. After the reaction was completed, H2O (5 mL) was added and stirred for 5 min. The mixture was extracted with EtOAc (2 x 5 mL), the organic phases were combined and dried with anhydrous Na2SO4. Evaporation of the solvent gave a pure 2,6-dichlorobenzylamine liquid in 93% yield (0.1 g, see Table 2, entry 1). | | References | [1] Journal of the Iranian Chemical Society, 2015, vol. 12, # 5, p. 873 - 878
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 9, p. 1111 - 1118 |
| | 2,6-Dichlorobenzylamine Preparation Products And Raw materials |
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