UPGL00004 manufacturers
- UPGL00004
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- $43.00 / 5mg
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2026-01-05
- CAS:1890169-95-5
- Min. Order:
- Purity: 97.93%
- Supply Ability: 10g
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| | UPGL00004 Basic information |
| Product Name: | UPGL00004 | | Synonyms: | UPGL00004;UPGL00004,UPGL-00004;Benzeneacetamide, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-;2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide;2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide , UPGL00004;UPGL00004, 10 mM in DMSO | | CAS: | 1890169-95-5 | | MF: | C25H26N8O2S2 | | MW: | 534.66 | | EINECS: | | | Product Categories: | | | Mol File: | 1890169-95-5.mol |  |
| | UPGL00004 Chemical Properties |
| density | 1.460±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | form | Solid | | pka | 9.23±0.50(Predicted) | | color | Off-white to gray | | InChIKey | MRYCNTHLPRENBA-UHFFFAOYSA-N | | SMILES | O=C(CC1=CC=CC=C1)NC(S2)=NN=C2N(CC3)CCC3NC4=NN=C(NC(CC5=CC=CC=C5)=O)S4 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | UPGL00004 Usage And Synthesis |
| Uses | UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1]. | | Biological Activity | UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, more selective for GAC than GLS2. | | in vitro | Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab effectively inhibited triple-negative breast cancer cell growth and tumor growth. | | in vivo | Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab inhibited tumor growth in a human xenograft model of breast cancer. | | target | | Target | Value | glutaminase C
(Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 29 nM
| | References | [1] Huang Q, et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293(10):3535-3545. DOI:10.1074/jbc.M117.810101 |
| | UPGL00004 Preparation Products And Raw materials |
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