DJ-V159
| 中文名称 | DJ-V159 |
|---|---|
| 中文同义词 | 化合物DJ-V159;N1,N3-双(4-氰基-3-(三氟甲基)苯基)间苯二甲酰胺;化合物DJ-V159,10 MM DMSO 溶液 |
| 英文名称 | DJ-V159 |
| 英文同义词 | DJ-V159;DJ-V159;DJ-V 159;1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-;DJV159,Inhibitor,Androgen Receptor,inhibit,DJ V 159;DJ-V-159, 10 mM in DMSO |
| CAS号 | 2253744-53-3 |
| 分子式 | C24H12F6N4O2 |
| 分子量 | 502.37 |
| EINECS号 | 604-604-1 |
| 相关类别 | |
| Mol文件 | 2253744-53-3.mol |
| 结构式 |  |
DJ-V159 性质
| 储存条件 | RT |
|---|---|
| 溶解度 | 溶于 DMSO（高达 60 mg/ml）。 |
| 形态 | 固体 |
| 颜色 | 米白色 |
| 稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
| InChIKey | VEVNLJLJLVESLL-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)=CC=C1)NC3=CC(C(F)(F)F)=C(C#N)C=C3 |
GPRC6A.
DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A.
DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S0083 | DJ-V159 DJ-V-159 | 2253744-53-3 | 5mg | 2596.23元 |
| 2026/03/03 | S0083 | DJ-V159 DJ-V-159 | 2253744-53-3 | 25mg | 7854.21元 |