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| | FFAR3 (GPR41) (Internal) Polyclonal Antibody Basic information |
| | FFAR3 (GPR41) (Internal) Polyclonal Antibody Chemical Properties |
| | FFAR3 (GPR41) (Internal) Polyclonal Antibody Usage And Synthesis |
| Description | GPR41 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). Several SCFAs have the potential to bind and activate GPR41, with pentanoate being the most potent agonist. GPR41 couples through the Pertussis toxin-sensitive Gi/o family and its expression has been described in adipose tissue and the colonic lumen. The activation of GPR41 induces an increase in intracellular Ca2+, ERK1/2 activation and a decrease in intracellular cAMP. Activation of GPR41 may be involved in intestinal inflammation. The predicted size for GPR41 is 39 kDa. Cayman’s GPR41 (Internal) Polyclonal Antibody detects a 45 kDa band by WB in cell lysates. | | References | [1] H TAZOE. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions.[J]. Journal of Physiology and Pharmacology, 2008, 59 Suppl 2: 251-262.
[2] ANDREW J BROWN. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.[J]. The Journal of Biological Chemistry, 2003, 278 13: 11312-11319. DOI: 10.1074/jbc.m211609200
[3] EMMANUEL LE POUL. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.[J]. The Journal of Biological Chemistry, 2003, 278 28: 25481-25489. DOI: 10.1074/jbc.m301403200 |
| | FFAR3 (GPR41) (Internal) Polyclonal Antibody Preparation Products And Raw materials |
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