LOR-253) manufacturers
- APTO-253 isomer
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- $2500.00
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2026-05-11
- CAS:1422826-80-9
- Purity:
- Supply Ability: 10g
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| | LOR-253) Basic information |
| Product Name: | LOR-253) | | Synonyms: | APTO-253
(APTO253;1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(6-fluoro-2-methyl-1H-indol-3-yl)-;APTO-253 isomer | | CAS: | 1422826-80-9 | | MF: | C22H14FN5 | | MW: | 367.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1422826-80-9.mol |  |
| | LOR-253) Chemical Properties |
| | LOR-253) Usage And Synthesis |
| Description | APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis. |
| | LOR-253) Preparation Products And Raw materials |
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